Cheyenne was the capital of the U.S. state of Wyoming.
During the 2012 apocalypse, Cheyenne was hit by massive earthquakes and engulfed by the Yellowstone Caldera's Ash Cloud, when it erupted earlier, destroying several of its buildings and killing several people living in the state. Cheyenne was then swept by a mega-tsunami in the Worldwide Flooding.
After the apocalypse ended, Cheyenne was left with extreme damage from the apocalyptic disasters and is rendered uninhabitable.
- Though Cheyenne isn't seen in the film, its possible that the city was destroyed along with the rest of the world during the 2012 apocalypse.